BDBM482158 BDBM50242742::TAE684

SMILES COc1cc(ccc1Nc1ncc(Cl)c(Nc2ccccc2S(=O)(=O)C(C)C)n1)N1CCC(CC1)N1CCN(C)CC1

InChI Key InChIKey=QQWUGDVOUVUTOY-UHFFFAOYSA-N

Data  58 IC50  449 Kd  21 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 482158   

TargetEphrin type-B receptor 4(Homo sapiens (Human))
Genomics Institute Of The Novartis Research Foundation

Curated by ChEMBL
LigandPNGBDBM482158(BDBM50242742 | TAE684)
Affinity DataIC50:  1.30E+3nMAssay Description:Inhibition of Tel-fused EphB4 kinase-mediated mouse BaF3 cell proliferationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEphrin type-B receptor 4(Homo sapiens (Human))
Genomics Institute Of The Novartis Research Foundation

Curated by ChEMBL
LigandPNGBDBM482158(BDBM50242742 | TAE684)
Affinity DataKd:  750nMAssay Description:Binding constant for EPHB4 kinase domainMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEphrin type-B receptor 4(Homo sapiens (Human))
Genomics Institute Of The Novartis Research Foundation

Curated by ChEMBL
LigandPNGBDBM482158(BDBM50242742 | TAE684)
Affinity DataEC50: >1.00E+3nMAssay Description:Inhibition of EphB4 by cellular assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed